PhD, Leiden University Medical Centre, Netherlands
MSc in Bioscience Technology, University of York
BSc Biology, University of York
Locating macromolecules and determining structures inside bacterial cells using electron cryotomography
Melia, C.E., Bharat, T.A.M.
BBA - Proteins and Proteomics, June 13th (2018)
Escaping Host Factor PI4KB Inhibition: Enterovirus Genomic RNA Replication in the Absence of Replication Organelles.
Melia CE*, van der Schaar HM*, Lyoo H, Limpens RWAL, Feng Q, Wahedi M, Overheul GJ, van Rij RP, Snijder EJ, Koster AJ, Bárcena M, van Kuppeveld FJ
Cell Reports. 2017 Oct 21:587-599. *Joint first authorship
Illuminating the Sites of Enterovirus Replication in Living Cells by Using a Split-GFP-Tagged Viral Protein.
van der Schaar HM*, Melia CE*, van Bruggen JA, Strating JR, van Geenen ME, Koster AJ, Bárcena M, van Kuppeveld FJ.
mSphere. 2016 Jul 6;1(4). *Joint first authorship
Correlative and integrated light and electron microscopy of in-resin GFP fluorescence, used to localise diacylglycerol in mammalian cells.
Peddie CJ, Blight K, Wilson E, Melia C, Marrison J, Carzaniga R, Domart MC, O'Toole P, Larijani B, Collinson LM.
Ultramicroscopy. 2014 Aug 143:3-14
Charlotte carried out her MSc research first at the University of York, working with Peter O’Toole, and later with Lucy Collinson at Cancer Research UK in London. Having developed a passion for light and electron microscopy through investigation of the nucleplasmic reticulum, Charlotte went on to undertake a PhD in the lab of Bram Koster in Leiden, the Netherlands, under the guidance of Montserrat Bárcena. Through the use of correlative light and electron microscopy, electron tomography, autoradiography and other techniques, this work explored the novel rearrangements of cellular endomembrane that are hijacked for replication of the picornavirus genome (replication organelles), generating new insights into their formation and morphology.